AB15. The expression of SOX7 decreases in gastric carcinomas and contributes to down-regulate the malignancy of the neoplasms and the growth of gastric tumor cells
Abstract

AB15. The expression of SOX7 decreases in gastric carcinomas and contributes to down-regulate the malignancy of the neoplasms and the growth of gastric tumor cells

Lin Chen, Jian-Xin Cui, Hong-Qing Xi, Bo Wei

Department of General Surgery, General Hospital of Chinese PLA, Beijing 100853, China

Objectives: To explore the expression level of SOX7 in gastric carcinomas and tumor cells, and to find any correlation between it and clinicopathologic features of the patients and between it and the growth of gastric tumor cells.

Methods: The detection of the expression of SOX7 was going through immunohistochemistry in 292 cases of gastric tumor paraffin-embedded specimens, western blot in 30 pairs of fresh frozen specimens and 3 cell lines. Flow cytometric analysis and MTT were performed in a certain cell line. Statistical analysis of clinicopathologic features was done by SPSS 17.0.

Results: The expression of SOX7 showed a negative correlation with tumor size (P<0.05), TNM stage (P<0.05), metastasis (P<0.05) and prognosis (P<0.05). The sox7 positive-expressing cells sorted by FCM grow significantly slower than others (P<0.05).

Conclusions: SOX7 expression was down-regulated in gastric carcinomas and correlated with the malignancy of the neoplasms in human body, such as metastasis, poor-prognosis, etc. The same effects were also conformed in gastric tumor cells.

Keywords: SOX7; gastric carcinomas; gastric tumor cells

Cite this abstract as: Chen L, Cui JX, Xi HQ, Wei B. The expression of SOX7 decreases in gastric carcinomas and contributes to down-regulate the malignancy of the neoplasms and the growth of gastric tumor cells. Transl Gastrointest Cancer 2013;2(S1):AB15. doi: 10.3978/j.issn.2224-4778.2013.s015