AB78. The relation among clinicopathologic features, different affected sites and ages of patients with gastric cancer patients

Objective: The clinical pathology database of 1,200 gastric cancer patients confirmed by pathology, which include 1,081 cases of adenocarcinoma, 16 cases of signet ring cell carcinoma, 81 cases of adenocarcinoma with signet ring cell carcinoma and 22 cases other types histologic type, was retrospectively reviewed and analyzed patients with gastric cancer from Jan 2008 to Dec 2009 in the Third Hospital of Harbin Medical University. To investigate the relation among different affected sites, mostly occurred locations clinicopathologic features, and ages of patients with gastric cancer .

Methods: The clinical data for 1,200 patients with gastric cancer in our hospital from Jan 2008 to Dec 2009 were analyzed with SPSS 19.0, including pathogenic sites, age, gender, tumor size, Borrmann type, general type and pathological differentiation type. For enumeration data, χ² test is used.

Results: In 113 cases of early gastric cancer, most of tumors occurred at lesser curvature of antrum (60, 53.1%); lesser curvature of corpus (29, 25.7%); angulus (14, 12.4%); cardia (10, 8.8%). In the four groups, there was significant difference between pathogenic sites and gender (χ²=2.37, P<0.05). There was no significant difference with age, tumor size, general type and pathological differentiation type; In 1,087 cases of advanced gastric cancer, the most predilection site were antrum (608, 55.9%), secondly gastric fundus and cardia (249, 22.9%) and gastric body (173, 15.9%). In the four groups divided according to predilection site, there was significant difference with gender (χ²=5.32, P<0.05). There was no significant difference with age, tumor size, Borrmann type, pathological differentiation type. The patients were divided into three groups (A: ≤40, B: 60) according to different ages, the total proportion of male and female was 2.3:1. The proportion of each group was 1.1:1, 2.4:1, 2.9:1. There was significant difference between the three groups (χ²=8.39, P<0.05); through the comparison for the three groups of pathology differentiation types, was 91.7% at most. However, the ratio of well differentiated adenocarcinoma increased as the growth of the age, which was statistical significant with poorly differentiated adenocarcinoma (χ²=16.74, P<0.05). There was no significant difference in the pathogenic sites groups in which the cases of location at lower third of stomach was most (649, 54.1%). There was no significant difference in the tumor size groups in which the cases of size (<2 cm ≤5 cm) was most (567, 47.3%). There was also no significant difference in Borrmann type groups in which the cases of Borrmann III was most (509, 46.8%).

Conclusions: Most of early gastric cancer occurred at lesser curvature of antrum, followed by the higher the location of gastric cancer, the number was fewer and proportion of women with relatively high; predilection site was gastric antrum in advanced gastric cancer, followed by the higher the location of gastric cancer, the percentage of men relatively increased; In addition, gastric cancer patients age is smaller which resulted in the proportion of women relatively increased; The older patients with gastric cancer, the proportion of well, poorly differentiated adenocarcinoma relatively increased.

Keywords: Gastric cancer; pathology; age; gender