AB81. Prognosis of one organ invaded by pTM gastric cancer treated with radical combined resection
Abstract

AB81. Prognosis of one organ invaded by pT4bM0 gastric cancer treated with radical combined resection

Ming-Zhi Cai

Department of Gastric Cancer Surgery, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Tianjin, China

Objectives: Combined resection is the main treatment for pT4b gastric cancer, including gastrectomy, D2 lymph node dissection and combined resection of invaded organs. This study is to investigate the clinicopathologic characteristics and prognostic factors of pT4b gastric cancer treated with radical combined resection according to different invaded organs.

Methods: A total of 244 patients with pT4bM0 gastric cancer who underwent radicial combined resection from 1994 to 2005 were enrolled, subjected to prognosis analysis. To analyse clinicopathologic features, surgical findings and survival rates according to different invaded organs.

Results: The overall 1-, 3-, 5-year survival rates of all the 244 cases were 66.1%, 39.1% and 28.2%. The 1-, 3-, 5-year survival rates of patients with transverse colonic invasion were 70.2%, 42.6% and 33.5%, significantly (P=0.038) better than those with other organ invasion. The 1-, 3-, 5-year survival rates of patients with pancreatic invasion were 59.2%, 27.7%, 6.9% and 72.3%, 44.6%, 34.7% in patients with other organ invasion respectively (P=0.022). According to the operation procedures used in pancreatic invasion patients, the 5-year survival rates in pancreatoduodenectomy (PD) group were 0%, and 15.9% in pancreatic body/tail resection group (P=0.015). Multivariate analysis demonstrated that histologic type, lymph node stage and pancreatic invasion were the independent prognostic factors in pT4b gastric cancer treated with radical combined resection.

Conclusions: As an independent prognostic factor, pancreatic invasion affected survival rates of patients. There was a significant difference in long-term survival rates between PD group and pancreatic body/tail resection group. PD is not recommended as the preferred treatment for patients who have pancreatic head invaded pT4b gastric cancer.

Keywords: Gastric cancer; resection; prognosis; pancreatic invasion; pancreatoduodenectomy (PD)

Cite this abstract as: Cai MZ. Prognosis of one organ invaded by pT4bM0 gastric cancer treated with radical combined resection. Transl Gastrointest Cancer 2013;2(S1):AB81. doi: 10.3978/j.issn.2224-4778.2013.s081