Multidisciplinary approach and targeted agents increase resectability of liver-limited metastases from colorectal cancer

The outcome of patients with initially unresectable metastatic colorectal cancer have greatly improved in the past years (1) and at least three important factors have certainly contributed: a multidisciplinary approach, the availability of targeted agents and the knowledge of the molecular pathways of metastatic colorectal cancer. On June 2013, Ye et al. (2) published on the Journal of Clinical Oncology the results of a single-center randomized trial investigating the effect of the addition of cetuximab to first-line chemotherapy for radical resection rate of liver metastases from colorectal cancer. An editorial by N. Kemeny accompanied the paper (1) and, on December 2013, a correspondence between the Authors and other international working groups was published on the same Journal (3-5).