03. Expression of CEBPB in human gastric carcinoma and its clinical significance

Objective: To explore the expression of CEBPB in gastric carcinoma tissues and its association with clinicopathological features and prognosis.
Methods: CEBPB protein expression levels were detected by immunohistochemistry method in resected gastric carcinomas and adjacent gastric mucosa tissues (n=81), and its association with clinicopathological features and prognosis were analyzed.
Results: The immunohistochemical staining for CEBPB was predominantly in the nuclear with some cytoplasmic staining. As a result, 16% of the gastric carcinomas was stained positively, whereas there was hardly positive expression in adjacent gastric mucosa tissues. There was a significant correlation between the expression of CEBPB and the M stage (P<0.05), the expression rate of CEBPB was higher in the patients with metastasis. CEBPB was also related with the poorer prognosis, and it can be used as a independent prognosis factor (HR: 2.544, 95%CI: 1.154-5.610, P=0.021).
Conclusions: Up-regulations of CEBPB might play an important role in the development, of gastric cancer which might be a potential therapeutic target.