Gianfranco Alpini, PhD
Scott & White and Texas A & M Health Science Center College of Medicine, Temple, TX, United States
Gianfranco D Alpini, PhD. Professor, Medicine and Systems Biology and Translational Medicine, Central Texas Veterans Health Care System, Scott & White and Texas A & M Health Science Center, College of Medicine, Dr. Nicholas C. Hightower Centennial Chair of Gastroenterology; Director of the Scott & White Digestive Disease Research Center.
As PI on several NIH and VA funded grants, Prof Alpini has established a strong track record of successful and productive research projects in the area of hepatobiliary pathobiology and pathophysiology. His research interest is focused on identifying and evaluating the functional and molecular effects of various signaling pathways that participate in theautocrine/paracrine regulation of biliary proliferation and differentiation, particularly in relation to cholestatic liver injury and cholangiocarcinoma.These include hormonal, growth factors, and bile acid-mediated signaling pathways.
His area of expertise includes factors that regulate hepatic/cell mitosis and apoptosis in particularthe regulation of the balance of proliferation and apoptosis by bile acids,neurotransmitters, gastrointestinal hormones, and angiogenic factors. In addition, he has expertise in epithelial transport mechanisms. He has a good general knowledge on the transduction pathways regulating the hyperplastic and neoplastic growth of the epithelial cells lining the stomach, small and largeintestine, gall bladder and pancreas. He has also expertise in the regulation of non-coding RNA (ncRNA) expressions, including microRNA and transcribed ultra conserved regions (T-UCRs), in hepatobiliary cancers and stem cells. In particular, how aberrant ncRNA expression contributes to the evasiveness of the cancer stem cells and resistance to chemotherapy.