@article{TGC1359,
author = {Vincenzo Cardinale and Guido Carpino and Yunfang Wang and Raffaele Gentile and Rossella Semeraro and Cristina Napoli and Vincenzo Pasqualino and Alice Fraveto and Alessia Torrice and Lola Reid and Eugenio Gaudio and Domenico Alvaro},
title = {Biliary tree stem/progenitor cells and perspectives in physiopathology and regenerative medicine},
journal = {Translational Gastrointestinal Cancer},
volume = {2},
number = {1},
year = {2013},
keywords = {},
abstract = {We have recently demonstrated the presence of cells expressing a constellation of endodermal markers in (peri)-biliary glands of extrahepatic bile ducts. These observations in situ in human tissues have been achieved by the in vitro demonstration that a subpopulation of cells [Pdx1+ (pancreatic and duodenal homeobox 1+)⁄Sox17+⁄EpCAM+ (epithelial cell adhesion molecule+)] isolated from the biliary epithelium have long-term (in vitro) persistence and self-renewal, and are able to give rise to a more restricted progeny towards different mature lineages (hepatocytes, cholangiocytes and β-pancreatic cells). The discovery of these cells, named human biliary tree stem/progenitor cells, opens a new scenario impacting many different aspects of hepato-gastroenterology including embryology of liver, biliary epithelium and pancreas, biliary pathophysiology, hep},
url = {https://tgc.amegroups.com/article/view/1359}
}