TY  - JOUR
AU  - Osório-Costa, Felipe
AU  - Carvalheira, José B. C.
PY  - 2013
TI  - TNF-α in obesity-associated colon cancer
JF  - Translational Gastrointestinal Cancer; Vol 2, No 4 (October 12, 2013): Translational Gastrointestinal Cancer
Y2  - 2013
KW  - 
N2  - Obesity is leading to an unparalleled increase in the incidence of metabolic diseases and cancers, including colon cancer. Research over the last few decades revealed obesity as a low-grade chronic inflammatory state, which has recently been implicated in colon carcinogenesis. Understanding the molecular links of obesity-associated inflammation with colon carcinogenesis is therefore more critical than ever. In this review we discuss the central role of TNF-α, the prototypical pro-inflammatory cytokine, in the pathophysiology of obesity-associated colon carcinogenesis.
UR  - https://tgc.amegroups.com/article/view/2860