@article{TGC2964,
author = {Jin Huang and Huabin Hu and Yangchun Xie and Youhong Tang and Wei Liu and Meizuo Zhong},
title = {Effects of TUBB3, TS and ERCC1 mRNA expressions on chemoresponse and clinical outcome of advanced gastric cancer by multiplex branched-DNA liquid chip technology},
journal = {Translational Gastrointestinal Cancer},
volume = {3},
number = {1},
year = {2013},
keywords = {},
abstract = {Objective: To analyze the impacts of β-tubulin-III (TUBB3), thymidylate synthase (TS) and excision repair cross complementation group 1 (ERCC1) mRNA expressions on chemoresponse and clinical outcomes of patients with advanced gastric cancer (GC) treated with docetaxel (TXT)/cisplatin (CDDP)/fluorouracil (FU) (DCF) regimen chemotherapy.
Methods: The study population consisted of 48 patients with advanced GC. All patients were treated with DCF regimen palliative chemotherapy. The mRNA expressions of TUBB3, TS and ERCC1 of primary tumors were examined by multiplex branched-DNA liquid chip technology.
Results: The patients with low TUBB3 mRNA expression had significantly higher response rate to chemotherapy than patients with high TUBB3 expression (P=0.011). There were no significant differences between response rate and TS or ERCC1 expression pattern. Median overall survival (OS) and median time to progression (TTP) were significantly longer in patients with low TUBB3 mRNA expression (P=0.002, P},
url = {https://tgc.amegroups.com/article/view/2964}
}