@article{TGC976,
author = {Rachael Glenister and Kelly McDaniel and Heather Francis and Julie Venter and Kendal Jensen and Giuseppina Dusio and Shannon Glaser and Fanyin Meng and Gianfranco Alpini},
title = {Therapeutic actions of melatonin on gastrointestinal cancer development and progression},
journal = {Translational Gastrointestinal Cancer},
volume = {2},
number = {1},
year = {2012},
keywords = {},
abstract = {Melatonin exerts a multitude of physiological functions including the regulation of the sleep cycle and circadian rhythm. Although the synthesis of melatonin in the pineal gland is regulated by changes in the light/dark cycle, the release of melatonin in the gastrointestinal tract is related to food consumption. Melatonin regulates antioxidative processes and it improves T-helper cell response by stimulating the production of specific cytokines. Melatonin is directly involved in preventing tumor initiation, promotion, and progression in a variety of cancers of the gastrointestinal tract including colorectal cancer, cholangiocarcinoma, hepatocarcinoma, and pancreatic carcinoma. This paper is a review of the literature regarding melatonin in the gastrointestinal tract and as a potential therapy for gastrointestinal cancers.},
url = {https://tgc.amegroups.com/article/view/976}
}