Type 3 deiodinase and consumptive hypothyroidism

Maynard et al. [April 10, 2014 issue (1)] described consumptive hypothyroidism (CH) caused by increased expression and activity of deiodinase, DIO3 within the tumor of a patient with gastrointestinal stromal tumor (GIST). Most of previously described cases of CH have occurred in hemangiomas; however, it now has become evident that CH can occur in other types of tumors, including fibrous tumors, basal-cell carcinoma, colon cancer, GISTs.