AB79. Vasculogenic mimicry and its correlation with TNM stage and prognosis in gastric adenocarcinoma
Abstract

AB79. Vasculogenic mimicry and its correlation with TNM stage and prognosis in gastric adenocarcinoma

Lei Zhu, Yingwei Xue

Department of Gastrointestinal Surgery, Affiliate Tumor Hospital of Harbin Medical University, Harbin, China

Objective: To study the relation between vasculogenic mimicry (VM) and tumor metastasis and TNM stage and prognosis in gastric adenocarcinoma

Methods: 100 paraffinembedded human GAC samples were collected, with detailed follow-up and clinicopathologic data. CD34/PAS double staining and CD31/PAS double staining, immunohistochemical staining of CK8&18 and laminin were performed to validate the exsistence of VM in GAC.

Result: The expression of HIF-1αand MMP-2 were both higher in the VM group than non-VM group. The survival rates of the VM group were shorter than that of non-VM group with a Kaplan-Meier survival analysis.

Conclusions: VM has a more frequent occurrence in the poorly differentiated GAC and is a potential indicator of poor prognosis for GAC. HIF-1α and MMP-2 may play a role in VM formation in GAC.

Keywords: Vasculogenic mimicry (VM); gastric adenocarcinoma; HIF-1α; MMP-2

Cite this abstract as: Zhu L, Xue YW. Vasculogenic mimicry and its correlation with TNM stage and prognosis in gastric adenocarcinoma. Transl Gastrointest Cancer 2013;2(S1):AB79. doi: 10.3978/j.issn.2224-4778.2013.s079