AB12. The summary of the staple basic researches on gastric carcinoma with liver metastases

Abstract: Gastric cancer represents the fourth common cancer with an estimate 1 million new cases annually in the world. The mainly pathological classification of gastric carcinoma is adenocarcinoma, and gastric adenocarcinoma is the second leading cause of cancer related mortality in the world. The status is also coincide with the data in Asia, such as China, Japan and Korea. The outcomes of gastric cancer are still poor, the mortality rate is approximately 75%, some patients are examined liver metastases lesions before the primary gastric cancer diagnosis, and the 5-year survival rate of stage IV (with distant organs and/or lymph nodes) is as low as 7%. Standard guidelines for the therapy of gastric cancer with liver metastasis have not been formulated yet. Some researches on the mechanism of how cancer cells settled in liver without being distinguished and swallowed mainly focused on related genes and other molecules, such as Nm23, KISS1, P53, HER2, C-met, PRL-3, MMP-9, Cathepsin B etc. Some genes expression increased in gastric cancer with liver metastasis, on the contrary, some genes can constrain the cancer cells transplant. Based on the investigation of molecules related to liver metastasis in gastric cancer, effect of single molecule on liver metastasis has been clarified and understood. However, the diagnosis and therapy of liver metastasis involve multiple molecules which have cross effect on each other. In consideration of this fact, expression and detection of relevant molecules in liver metastasis should be investigated simultaneously.

Keywords: Gastric cancer; adenocarcinoma; liver metastasis; molecular research