AB36. Relationship between ZNF139 and MMP-2, MMP-7, ICAM-1 in SGC7901 and SGC7901/ADR cell lines
Abstract

AB36. Relationship between ZNF139 and MMP-2, MMP-7, ICAM-1 in SGC7901 and SGC7901/ADR cell lines

Yong Li, Qun Zhao, Bi-Bo Tan, Li-Qiao Fan, Qing-Wei Liu, Zhi-Kai Jiao, Xüe-Feng Zhao, Ying-Jie Hao

Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050051, China

Objective: To investigate the expressions and significance of zinc finger protein 139 (ZNF139), MMP-2, MMP-7, ICAM-1 in in human gastric carcinoma cell lines SGC7901 and SGC7901/ADR.

Methods: The expressions of ZNF139, MMP-2, MMP-7, ICAM-1 were determined with RT-PCR and Western blot in in SGC7901 and SGC7901/ADR cell lines.

Results: The expressions of ZNF139, MMP-2, MMP-7, ICAM-1 were higher in SGC7901/ADR than in SGC7901 (all P<0.05). In SGC7901 there was positive correlativity between ZNF139 and MMP-2, ZNF139 and ICAM-1, MMP-2 and MMP-7, MMP-7 and ICAM-1 protein (all P<0.05). In SGC7901/ADR, positive correlativity was found between ZNF139 and MMP-7, MMP-2 and MMP-7 protein (all P<0.05), and no other statistical correlativity was found.

Conclusions: ZNF139 may be involved in invasion and metastasis of gastric cancer by regulating MMP-2, MMP-7, ICAM-1 genes.

Keywords: Zinc finger protein 139; gastric cancer; multidrug resistance; invasion, migration

Cite this abstract as: Li Y, Zhao Q, Tan BB, Fan LQ, Liu QW, Jiao ZK, Zhao XF, Hao YJ. Relationship between ZNF139 and MMP-2, MMP-7, ICAM-1 in SGC7901 and SGC7901/ADR cell lines. Transl Gastrointest Cancer 2013;2(S1):AB36. doi: 10.3978/j.issn.2224-4778.2013.s036