Chao Yan, Zheng-Gang Zhu, Min Yan, Jun Chen, Min Xiang, Ming-Min Chen, Bing-Ya Liu, Yan-Zhen Lin
Objective:
To investigate the value of serum tumor markers in predicting peritoneal metastasis of gastric cancer.
Methods:
The preoperative serum levels of CA125, CA19-9, CA72-4, and CEA were measured in 1,348 gastric cancer patients, and the results of these tumor markers were compared with surgical and pathological findings.
Results:
Receiver operating characteristic (ROC) analysis showed that the accuracy of the serum CA125 level in the determination for gastric cancer with peritoneal metastasis was the highest (area under ROC curve of CA125, CA19-9, CA72-4, and CEA was 0.85, 0.61, 0.71, and 0.43, respectively). ROC analysis further showed that the diagnostic value of serum CA125 level for predicting ascites was rather high (area under ROC curve was 0.97). A significantly direct correlation was also observed between the volume of ascites and serum CA125 level (Ps=0.686). When the positive result was defined as CA125 level over cut-off value (35 U/mL), the sensitivity, specificity, positive predictive value, negative predivtive value, and accuracy of serum CA125 level in predicting peritoneal metastasis of gastric cancer were 43.6% (41/94), 96.5% (1,210/1,254), 48.2% (41/85), 95.8% (1,210/1,263), and 92.8% (1,251/1,348), respectively. The sensitivity of serum CA125 in predicting peritoneal metastasis for gastric cancer with ascites was higher than that for those patients without ascites (79.4% vs. 23.3%, P
Conclusions:
The value of preoperative serum CA125 level in predicting peritoneal metastasis of gastric cancer was relatively high, and the serum CA125 level was correlated with the volume of ascites.
