AB11. Association between SNPs at 3'-UTR of apoptosis genes CASP3, CASP7 and risk of gastric adenocarcinoma in a north-eastern Chinese population
Abstract

AB11. Association between SNPs at 3'-UTR of apoptosis genes CASP3, CASP7 and risk of gastric adenocarcinoma in a north-eastern Chinese population

Fei-Hu Yan, Chun-Hui Zhang, Jia-Yin Liu, Yan-Qiao Zhang, Xiao-Yi Huang

Tumor Hospital Affiliated to Harbin Medical University, Harbin 150081, China

Objective: To explore the association of SNPs at the 3'-UTR of apoptosis genes CASP3 and CASP7 with the risk of gastric cancer among Han Chinese in the northeastern region of China.

Methods: In a case-control study of 1,000 patients with gastric cancer and 1,036 cancer-free controls with frequency matching on age and sex. We genotyped four potentially functional SNPs (rs1049253 T/C and rs1049216 T/C in CASP3, rs4353229 T/C and rs12247479 G/A in CASP7) by using Taqman assays and evaluated their associations with risk of gastric cancer by using logistic regression analyses.

Results: Compared with the GG/AG genotypes, the CASP7 rs12247479 AA genotype was associated with 0.560-fold decreased risk (P=0.036, 95% CI =0.325-0.964) of gastric cancer, but no associations were found for the other three SNPs. After gastric cancer cases were stratified according to sex, age, smoking and drinking data, this risk was more evident in subgroups of nonsmokers, OR =0.506 (P<0.01, 95% CI =0.407-0.629).

Conclusions: Potentially functional SNP in the microRNA binding sites at the 3'-UTR of apoptosis genes CASP7 rs12247479 variants may contribute to risk of gastric cancer.

Cite this abstract as: Yan FH, Zhang CH, Liu JY, Zhang YQ, Huang XY. Association between SNPs at 3'-UTR of apoptosis genes CASP3, CASP7 and risk of gastric adenocarcinoma in a north-eastern Chinese population. Transl Gastrointest Cancer 2015;4(S1):AB11. doi: 10.3978/j.issn.2224-4778.2015.s011