AB41. The expression and clinical significance of polycomb-repressive complex 2 component SUZ12 in colorectal cancer
Abstract

AB41. The expression and clinical significance of polycomb-repressive complex 2 component SUZ12 in colorectal cancer

Yong-Hui Su, Bing-Zong Hou, Jia-Qi Xu, Ju-Yuan Pu, Xiao-Ling Li

The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China

Objective: To investigate the role of polycomb-repressive complex 2 component SUZ12 in colorectal cancer.

Methods: Expression of SUZ12 was studied in archived specimens from 76 colorectal cancer patients by immunohistochemistry. Relationships between SUZ12 expression and clinicopathological characters were analyzed.

Results: Expression of SUZ12 protein in colorectal cancer tissues was significantly higher than that in paratumor tissues (9.24±4.47 vs. 3.45±2.78, P<0.01). SUZ12 expression was significantly correlated with tumor differentiation (P=0.014), TNM stage (P=0.016) and lymph nodes metastasis (P=0.036), but not with the patients age, gender, tumor location, tumor size or tumor invasion (P>0.05).

Conclusions: Over expression of SUZ12 is associated with more aggressive colorectal cancer and might be a biomarker for metastatic colorectal cancer.

Cite this abstract as: Su YH, Hou BZ, Xu JQ, Pu JY, Li XL. The expression and clinical significance of polycomb-repressive complex 2 component SUZ12 in colorectal cancer. Transl Gastrointest Cancer 2015;4(S1):AB41. doi: 10.3978/j.issn.2224-4778.2015.s041