Can Milan criteria be expanded effectively for liver transplantation in patients with HCC?

The Milan hepatocellular carcinoma (HCC) criteria emerged as the worldwide standard criteria for liver transplant eligibility. However, it has been observed that selected patients with more advanced tumor stage can achieve equivalent outcomes. A large retrospective analysis from Xu et al. comparing the Hangzhou HCC criteria with other expanded criteria suggests the Hangzhou criteria can offer the broadest application of liver transplantation for HCC patients without detriment in survival.