Hepatic angiomyolipoma, inflammatory variant: a case report and review of literature

Hepatic angiomyolipoma (AML) is a rare neoplasm. Based on its wide histomorphological range, several distinctive histological variants have been described. However, hepatic AML displaying predominantly or exclusively inflammatory pattern closely mimicking inflammatory pseudotumor (IPT) is exceptionally rare with less than fifteen cases reported so far. We describe another case of hepatic inflammatory AML in a 54-year-old woman who presented with fatigue and vague abdominal pain. There was no history of fever or jaundice. On examination, there was mild tenderness in the right hypochondrium with mild hepatomegaly. Liver function tests were within normal limits. The patient was seronegative for hepatitis B and hepatitis C. A liver mass was detected on radiological examination which was resected. Histopathological examination revealed a neoplasm rich in lymphoplasmacytic cells with foci of spindle cells which on immunohistochemistry (IHC) were positive for melanocytic markers like Melan A and HMB45 confirming the diagnosis of inflammatory hepatic AML.