01. Expressions of 14-3-3 bate protein in human gastric carcinoma and clinical significance

Objective: To investigate the expressions of 14-3-3 bate and their clinicopathological characteristic in gastric carcinoma.
Methods: A cohort of 120 cases of human gastric cancer tissues and 40 cases of normal tissues were accrued from the Third Affiliated Hospital of Harbin Medical University form April 2010 to October 2010. The expressions of 14-3-3 bate protein in human gastric cancer tissues and normal gastric tissues were detected by immunohistochemistry, explore the relationship between 14-3-3 bate protein expression and clinic pathological features in human gastric carcinoma.
Results: The positive expression rates of 14-3-3 bate protein were 70.0%, 22.5% in human gastric cancer tissues and normal gastric tissues,respectively. The expression of 14-3-3 bate protein in different groups was significantly different (χ²=27.809, P<0.001). The expressions of 14-3-3 bate protein had no correlation with age, sex, tumor location, Borrmann type and histological type (P>0.05). The expressions of 14-3-3 bate protein was associated with tumor size, the depth of tumor invasion, lymph node metastasis and TNM stage (P<0.05).
Conclusions: (I) The expression rates of 14-3-3 bate were significant higher in gastric carcinoma than normal gastric tissues. The expression of 14-3-3 bate was associated with tumor size and the depth of tumor invasion, and 14-3-3 bate protein interpromoted in the processes of carcinogenesis, progression, invasion and metastasis of gastric carcinoma. (II) The abnormally expressions of 14-3-3 bate protein is significantly associated with the incidence of lymph node metastasis. (III) 14-3-3 bate protein can be the indicators to judge the biological behavior of gastric carcinoma.